Cynicism will protect you here but irreparably damage your heart once you start to see it

We live in a hollow world

A person named Andrew who tried to do a kindness for me reached out some number of months ago to help me get a new job. I had to turn it down, but that’s another matter entirely. The reason I’m talking about this is Andrew said something in September over text that resonated with a something said on a phone call with another person last night.

Medac’s had the worst time getting treosulfan to market in the United States. But to their end the development of new types of therapeutics like Casgevy and other products which require BMT are making their way to market. The barrier to insurance reimbursement of off-label conditioning regimens such as treosulfan for casgevy is quite thin due to busulfan’s hepatotoxicity. There’s a small but not rare possibility of multi-organ failure from busulfan that’s avoided due to a difference with where treosulfan is metabolized. The pharmaceutical that’s used to combat this symptom is owned by Jazz pharmaceuticals and it costs a lot.